AI integration into medical education and practice has its benefits and risks. This national web-based cross-sectional survey on Egyptian medical staff and students aimed to assess knowledge, attitudes, and concerns regarding the use of AI. This study comprised 2765 medical students and 500 medical staff, with a mean age of 20.8 and 29.9 years, respectively, and higher percentages of females among both groups. Medical students demonstrated satisfactory knowledge of AI compared to medical staff (p < 0.001). Unfortunately, the majority of both groups (80.4% of staff and 81.6% of students) expressed negative attitudes toward AI use. Male participants had significantly higher attitude scores than females in both groups.
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